5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) is a powerful and relatively obscure psychedelic and entheogen of the tryptamine class. It is found in a wide variety of plant species, as well as in the venom of a single psychoactive toad species (Bufo Alvaris). Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen by South American shamans for thousands of years.[1] In modern times, however, it is primarily acquired in its synthetic powder form through the use of online research chemical vendors.

When taken as a drug in its purified or synthetic form, 5-MeO-DMT is vaporized, insufflated, or injected and is active at a dose of as little as 2 mg. 5-MeO-DMT is active orally when taken with an MAOI, but according to numerous reports this combination often tends to be extremely unpleasant and has a strong body load.

5-MeO-DMT or 5-methoxy-N,N-dimethyltryptamine is a ring-substituted indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to a terminal amine group via an ethyl side chain. 5-MeO-DMT is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O−; it also contains two methyl groups CH3- bound to the terminal amine RN of its tryptamine backbone (DMT). 5-MeO-DMT is the N-substituted methyl homologue of 5-MeO-MiPT, although it radically differs in its effects.


Tactile enhancement – This particular component is perhaps the most overwhelming sensation within the entirety of the 5-MeO-DMT experience. It increases the intensity of tactile sensations to such an overwhelming extent that it can induce a sensation of sustained and repeatable full body orgasm within every nerve ending across the entire body to a degree not found within any other psychedelic drug. The experience of this results in the perception of having a difficulty sustaining the act of breathing. It is worth noting, however, that this is not a genuine or dangerous experience of respiratory depression and is considered to be safe.
Bodily control enhancement
Bodily pressures
Changes in gravity
Motor control loss
Perception of increased weight
Pupil dilation
Skin flushing
Temperature regulation suppression
Cognitive effects
Analysis enhancement
Conceptual thinking
Subconscious communication
Emotion enhancement
Increased music appreciation
Memory suppression
Ego death
Thought connectivity
Time distortion
Unity and interconnectedness

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